Invitrogen™ RPL7A Monoclonal Antibody (OTI4D5)

Catalog No.	Quantity
PIMA527533	100 μL

Catalog No. PIMA527533 Supplier Invitrogen™ Supplier No. MA527533

Description

Mouse Monoclonal Antibody

RPL7A Monoclonal Antibody for Western Blot, IHC (P)

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Specifications

• Antigen: RPL7A
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI4D5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Rpl7a
• Gene Accession No.: P12970, P62424
• Gene Alias: 60S ribosomal protein L7a; L7A; Large ribosomal subunit protein eL8; PLA-X polypeptide; ribosomal protein L7a; RPL7A; Surf3; SURF-3; surfeit 3; surfeit locus protein 3; thyroid hormone receptor uncoupling protein; TRUP
• Gene Symbols: Rpl7a
• Host Species: Mouse
• Immunogen: Human recombinant protein fragment corresponding to amino acids 2-266 of RPL7A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27176, 6130
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b