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Invitrogen™ RPUSD3 Polyclonal Antibody
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Catalog No. PIPA532068
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100 μL
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PIPA532068 100 μL
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Catalog No. PIPA532068 Supplier Invitrogen™ Supplier No. PA532068
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: SK-N-SH. Predicted reactivity: Mouse (81%), Rat (84%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RNA Pseudouridine Synthase D3 (RPUSD3) is a gene that encodes a pseudouridine synthase, an enzyme responsible for catalyzing the isomerization of uridine to pseudouridine in RNA molecules. This post-transcriptional modification is crucial for the stability and function of tRNAs and rRNAs. RPUSD3, along with other pseudouridine synthases such as PUS1, PUSL1, and TRUB2, is predicted to localize to mitochondria, indicating its role in mitochondrial RNA processing and maturation. The pseudouridylation activity provided by RPUSD3 is essential for the proper folding and functionality of mitochondrial RNAs, which are fundamental for the biogenesis of the mitochondrial electron transport chain and ATP synthase. While detailed structural insights into RPUSD3 are not yet fully characterized, its enzymatic function is critical in maintaining cellular energy metabolism and overall mitochondrial health.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RPUSD3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene RPUSD3
Gene Accession No. Q6P087
Gene Alias AI527266; Mitochondrial mRNA pseudouridine synthase RPUSD3; RGD1307582; RNA pseudouridylate synthase domain containing 3; RNA pseudouridylate synthase domain-containing protein 3; Rpusd3
Gene Symbols RPUSD3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RPUSD3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 285367
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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