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Apexbio Technology LLC RS 17053 hydrochloride 169505-93-5 5mg
Supplier: Apexbio Technology LLC B65325
RS 17053 hydrochloride (CAS 169505-93-5) is a selective antagonist of the 1A-adrenergic receptor exhibiting markedly higher affinity for this subtype compared to 1B and 1D receptors in rat tissues (30 100-fold selectivity) The 1A-adrenergic receptor is widely expressed and mediates responses such as smooth muscle contraction cardiac stimulation hepatic glycogenolysis and regulation of cell proliferation and apoptosis Notably RS 17053 distinguishes functionally distinct 1A-adrenoceptor populations demonstrating substantially lower affinity ( 100-fold) for contractile 1A receptors in rat portal vein and human prostate relative to those in rat vas deferens or recombinant systems This pharmacological profile supports its use in characterizing adrenergic receptor subtypes and investigating receptor heterogeneity in various tissues
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