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Invitrogen™ RSPO2 Monoclonal Antibody (CL14321)
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Catalog No. MA563027
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MA563027 100 μL
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Catalog No. MA563027 Supplier Invitrogen™ Supplier No. MA563027
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Description

Mouse Monoclonal Antibody

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RSPO2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CL14321
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RSPO2
Gene Accession No. Q6UXX9, Q8BFU0
Gene Alias 2610028F08Rik; AA673245; CRISTIN2; cristin-2; cysteine-rich and single thrombospondin domain-containing protein 2; D430027K22; ftls; hRspo2; mCristin-2; RGD1562331; Roof plate-specific spondin-2; Rspo2; R-spondin 2; R-spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin-2; UNQ9384/PRO34209
Gene Symbols RSPO2
Host Species Mouse
Immunogen Recombinant protein corresponding to Human RSPO2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 239405, 340419
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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