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Invitrogen™ RT1.Bu Monoclonal Antibody (OX-3)
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Catalog No. p-7177930
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PIMA170006 250 μg
PIMA517413 500 μg
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Catalog No. PIMA170006 Supplier Invitrogen™ Supplier No. MA170006
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Description

Mouse Monoclonal Antibody

anti-rat RT1.Bu monoclonal antibody recognizes a polymorphic determinant on rat Ia present on Lewis, Wistar, and AO rat strains (although it is apparently expressed in lower amounts in AO rats) but not BN, DA, or PVG/c strains. This antibody also cross-reacts with mouse strains (MHC haplotypes b and s) and analysis of recombinant mouse strains shows that the determinant maps to the I-A region and correlates with mouse Ia specificity 9. Recognizes Ia antigens on approximately 18% of thymocytes but does not significantly label the majority of peripheral T lymphocytes. Thus, this antibody is particularly useful for distinguishing Ia positive cells from different rat strains and has been used in the recognition of cells of donor origin in bone marrow reconstituted radiation chimeras.

RT1.Bu is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. The RT1 complex in rats is analogous to the human HLA and mouse H2 MHC regions and encompasses a variety of class I and class II genes involved in antigen presentation. RT1.Bu is one such class I MHC gene, encoding a protein essential for the presentation of endogenous peptides to cytotoxic T cells. This interaction is vital for the immune system's ability to recognize and eliminate infected or malignantly transformed cells. The RT1.Bu gene is crucial for studying immune responses, particularly in transplantation immunology and autoimmune disease models, due to its role in histocompatibility and immune regulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RT1.Bu
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Classification Monoclonal
Clone OX-3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RT1-Ba
Gene Accession No. P20037
Gene Alias activated B cell RT1Bl alpha chain; BA1; MHC class II antigen RT1.B alpha chain; rano class II histocompatibility antigen, B alpha chain; rat class I Bu; RT1 class II antigen, Ba chain; RT1 class II, locus Ba; RT1-B alpha; RT1-Ba; RT1-Bu
Gene Symbols RT1-Ba
Host Species Mouse
Immunogen Rat thymocyte membrane glycoprotein.
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 309621
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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