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Rubicon Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501733421 Shop All Proteintech Group Inc Products
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50-173-3421 150 μL
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Catalog No. 50-173-3421 Supplier Proteintech Group Inc Supplier No. 214441AP150UL
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Description

Rabbit Polyclonal Antibody

Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.

Specifications

Antigen Rubicon
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RUBCN
Gene Accession No. Q80U62, Q92622
Gene Alias Baron, KIAA0226, RUBCN, Rubicon
Gene Symbols Rubcn
Host Species Rabbit
Immunogen Rubicon Fusion Protein Ag13715
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100502698, 303885, 9711
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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