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Invitrogen™ RUNX2 Polyclonal Antibody
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Catalog No. 01675341
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Catalog No. Quantity
01-675-341 100 μg
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Catalog No. 01-675-341 Supplier Invitrogen™ Supplier No. PA141519
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Description

Rabbit Polyclonal Antibody

PA1-41519 detects RUNX2 in chicken, chimpanzee, new world monkey, equine, human and mouse samples. This antibody is predicted to react with rat, pufferfish, zebrafish, and xenopus based on sequence homology.

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUNX2
Applications Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene RUNX2
Gene Accession No. Q08775, Q13950, Q9XSB7
Gene Alias Acute myeloid leukemia 3 protein; AKV core binding factor; Aml3; AML-3; Cbf; Cbfa1; Cbfa-1; CBF-alpha-1; CCD; CCD1; CLCD; core binding factor alpha 1; core binding factor alpha 1 subunit; core-binding factor subunit alpha-1; core-binding factor, runt domain, alpha subunit 1; LOW QUALITY PROTEIN: runt-related transcription factor 2; LS3; Oncogene AML-3; Osf2; OSF-2; osteoblast-specific transcription factor 2; PEA2aA; PEA2-alpha A; PEBP2 alpha A; PEBP2A; Pebp2a1; PEBP2aA; PEBP2-alpha A; Pebpa2a; Polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt related transcription factor 2; runt-related transcription factor 2; RUNX 2; RUNX family transcription factor 2; Runx2; RUNX-2; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; transcription factor RUNX2; transcription factor RUNX2/CBFA1
Gene Symbols RUNX2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to somewhere between amino acids 250-300 of human RUNX2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100033890, 12393, 373919, 860
Target Species Human, Mouse, Monkey, Horse, Chicken
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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