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RWDD3 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501733936 Shop All Proteintech Group Inc Products
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50-173-3936 150 μL
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Catalog No. 50-173-3936 Supplier Proteintech Group Inc Supplier No. 227371AP150UL
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Description

Rabbit Polyclonal Antibody

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Specifications

Antigen RWDD3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.55 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RWDD3
Gene Accession No. Q9Y3V2
Gene Alias RSUME, RWD domain containing 3, RWDD3
Gene Symbols RWDD3
Host Species Rabbit
Immunogen RWDD3 Fusion Protein Ag18674
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25950
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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