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RYR2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 197651AP150UL

Encompass_Preferred

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Catalog No. 50-173-2532


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Description

Description

This antibody detects a band at ∽250 kDa which has been reported.

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.
Specifications

Specifications

RYR2
Polyclonal
Unconjugated
RYR2
ARVC2, ARVD2, ryanodine receptor 2 (cardiac), ryanodine receptor 2, cardiac, RYR2, VTSIP
Rabbit
Antigen Affinity Chromatography
RUO
20191, 6262
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
E9Q401, Q92736
RYR2
Peptide
150 μL
Primary
Human, Mouse
Antibody
IgG
SDS
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