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Invitrogen™ S-arrestin Monoclonal Antibody (PDS-1)
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Catalog No. 01674950
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Catalog No. Quantity
01-674-950 50 μL
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Catalog No. 01-674-950 Supplier Invitrogen™ Supplier No. MA15872
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Description

Mouse Monoclonal Antibody

MA1-5872 detects Retinal S-antigen in human, porcine, bovine and rat samples. MA1-5872 has been successfully used in Western blot and immunohistochemistry procedures. The MA1-5872 immunogen is porcine S-antigen.

S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
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Specifications

Antigen S-arrestin
Applications Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone PDS-1
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene SAG
Gene Accession No. P08168, P10523, P15887, P79260
Gene Alias 48 kDa protein; A930001K18Rik; Arr1; arrestin; arrestin 1; arrestin1; arrestin-1; DKFZp686D1084; DKFZp686I1383; Irbp; photoreceptor protein/alleged cGMP phosphodiesterase activation modulator; put. S-antigen C-terminus; retinal S antigen; retinal S-antigen; retinal S-antigen (48 KDa protein); rod arrestin; rod photoreceptor arrestin; RP47; Sag; S-AG; SAGMR; SANTI; S-antigen; S-antigen visual arrestin; S-antigen, retina and pineal gland (arrestin); S-antigen; retina and pineal gland (arrestin); S-arrestin; S-arrestin short form; visual arrestin 1
Gene Symbols SAG
Host Species Mouse
Immunogen Porcine S-antigen from Balb/c Ag 8.653 cells.
Purification Method Protein G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25539, 280922, 397151, 6295
Target Species Human, Rat, Bovine, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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