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Invitrogen™ SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Rabbit Monoclonal Antibody (P05DHuRb)

Catalog No. 703971
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70-397-1 100 μg
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Catalog No. 70-397-1 Supplier Invitrogen™ Supplier No. 703971
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody has a human Fab with a kappa light chain, and Rabbit Fc. It recognizes the RBD domain of SARS CoV2 Spike protein. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. This antibody is not recommended for the Western blot application. This antibody is not recommended for the Neutralization application.

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SARS-CoV-2 Spike Protein (RBD) Chimeric
Applications ELISA, Flow Cytometry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone P05DHuRb
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Alias Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2
Host Species Rabbit
Immunogen This antibody was developed using computationally derived variants of SARS-CoV antibody structures and is shown to bind Spike Protein S1 subunit (RBD) of SARS CoV2.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG κ
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