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Invitrogen™ SARS-CoV-2 Spike Protein (RBD) (P.1) Fc Chimera Recombinant Protein

Catalog No. PIRP88479
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100 μg
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Catalog No. Quantity
PIRP88479 100 μg
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Catalog No. PIRP88479 Supplier Invitrogen™ Supplier No. RP88479
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Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. The mutations were identified in the SARS-CoV-2 varient known as P.1.

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.
TRUSTED_SUSTAINABILITY

Specifications

For Use With (Application) Control, Neutralization
Format Lyophilized
Formulation PBS with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Molecular Weight (g/mol) 55.9 kDa
Name SARS-CoV-2 Spike Protein (RBD) (P.1) Fc Chimera
pH Range 7.4
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2
Common Name SARS-CoV-2 Spike Protein RBD
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence SARS-CoV-2 spike RBD (Accession # YP_009724390.1), amino acids Arg319-Phe541 with K417T, E484K, N501Y substitutions and a C-terminal human IgG1 Fc region
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade >95% as determined by SDS-PAGE.
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