Tocris Bioscience™ SB 202190

Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.

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Specifications

Chemical Identifiers

• CAS: 152121-30-7
• Molecular Formula: C20H14FN3O

• Quantity: 50 mg
• Formula Weight: 331.35
• Purity: >99%
• Molecular Weight (g/mol): 331.35
• Chemical Name or Material: SB 202190

Safety and Handling

Recommended Storage

Store at -20°C