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SBE 13 hydrochloride, Tocris Bioscience™

Catalog No. 429210
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10mg
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This item is not returnable. View return policy

Description

Potent and selective PLK1 inhibitor

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.

Specifications

CAS 1052532-15-6
Molecular Formula C24H28Cl2N2O4
Quantity 10 mg
Synonym sbe13 hydrochloride, sbe 13 hydrochloride, sbe 13 hcl, n-4-6-chloro-3-pyridinyl methoxy-3-methoxyphenyl methyl-3,4-dimethoxybenzeneethanamine hydrochloride, n-4-6-chloropyridin-3-yl methoxy-3-methoxybenzyl-2-3,4-dimethoxyphenyl ethanamine, c24h27cln2o4.clh, sbe-13 hcl;sbe13 hcl, sbe 13 hydrochloride hplc, n-4-6-chloropyridin-3-yl methoxy-3-methoxyphenyl methyl-2-3,4-dimethoxyphenyl ethan-1-amine-hydrogen chloride 1/1
InChI Key QBGSVDJLQQXEGG-UHFFFAOYSA-N
SMILES COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
IUPAC Name N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride
Molecular Weight (g/mol) 479.398
PubChem CID 11948807
Formula Weight 479.4
Percent Purity >99%
Chemical Name or Material SBE 13 hydrochloride
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Safety and Handling

Recommended Storage Desiccate at Room Temperature
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