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Apexbio Technology LLC SC75741 913822-46-5 10mg
Supplier: Apexbio Technology LLC B474910
SC75741 is a small-molecule inhibitor targeting the NF- B signaling pathway with an EC50 of approximately 200 nM NF- B is a transcription factor complex regulating immune responses through control of cytokines and chemokines production SC75741 inhibits influenza virus replication by suppressing NF- B-mediated host-dependent viral growth Experiments in MDCK cells have shown optimal suppression of virus replication at concentrations around 5 M post-infection Additionally experiments conducted in human alveolar epithelial A549 cells infected with influenza strains including H5N1 and H7N7 indicated dose-dependent reduction in viral titers upon treatment SC75741 administration in influenza-infected mice showed reduced viral load and lowered expression of cytokines such as IL-6 and IP-10 indicating its suitability for studying virus-induced inflammatory responses and replication
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