Invitrogen™ SCAMP5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1737

Catalog No. PA1737

Description

PA1-737 detects secretory carrier membrane protein 5 (SCAMP 5) from rat brain extract. PA1-737 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~25 kDa protein representing SCAMP 5 from rat brain extract. PA1-737 immunizing peptide corresponds to amino acid residues 217-233 from rat SCAMP 5. This sequence is 94% conserved in mouse. PA1-737 immunizing peptide (Cat. # PEP-152) is available for use in neutralization and control experiments.

Secretory carrier membrane proteins (SCAMPs) are proteins that are components of post-Golgi membranes. These proteins are implicated to function in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments that are involved in the recycling of cell surface receptors and endocytosis. In neurons, SCAMPs are associated with synaptic vesicles, secretion granules and transporter vesicles. SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1-3 contain cytoplasmic N-terminal regions with NPF repeats. NPF repeats are found to interact with EH domain proteins that function in budding of transport vesicles from the plasma membrane or the Golgi complex. SCAMPs 4 and 5 lack the N-terminal NPF repeats. SCAMPs 1-4 are all ubiquitously coexpressed while SCAMP 5 is only detectable in the brain. Studies show that SCAMP 5 is expressed late in development which is coincident with expansion of mature synapses.

Specifications

• Antigen: SCAMP5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCAMP5
• Gene Alias: hSCAMP5; Sc5; scamp5; scamp5a; Secretory carrier membrane protein 5; secretory carrier membrane protein 5a; secretory carrier membrane protein 5-like; secretory carrier-associated membrane protein 5; wu:fc30b07; zgc:77438
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 65171
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q9JKE3
• Gene Symbols: SCAMP5
• Immunogen: Synthetic Peptide: C N(217) Q P Q T Q Y S A T P N Y T Y S N(233).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG