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Tocris Bioscience™ SCH 51344

Catalog No. 528050
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52-805-0 50 mg
52-801-0 10 mg
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Catalog No. 52-805-0 Supplier Tocris Bioscience™ Supplier No. 5280/50
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Description

Potent MTH1 inhibitor

SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

Specifications

Purity >99%
Quantity 50 mg
Product Type SCH 51344
Molecular Weight (g/mol) 316.35
Inhibitors SCH 51344

For Research Use Only

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