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Invitrogen™ SCN4B Polyclonal Antibody
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Catalog No. PIPA5101890
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100 μL
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PIPA5101890 100 μL
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Catalog No. PIPA5101890 Supplier Invitrogen™ Supplier No. PA5101890
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SCN4B.

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCN4B
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SCN4B
Gene Accession No. Q8IWT1
Gene Alias ATFB17; Gm1471; LQT10; Navbeta4; Scn4b; sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; sodium channel, voltage gated, type IV beta subunit; sodium channel, voltage-gated, type IV, beta subunit; sodium voltage-gated channel beta subunit 4; voltage gated sodium channel beta 4 subunit
Gene Symbols SCN4B
Host Species Rabbit
Immunogen A synthesized peptide derived from human SCN4B(Accession Q8IWT1), corresponding to amino acid residues K184-V228.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6330
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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