Invitrogen™ SCNN1B Polyclonal Antibody

Catalog No.	Quantity
PIPA5106890	100 μL

Catalog No. PIPA5106890 Supplier Invitrogen™ Supplier No. PA5106890

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SCNN1B.

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. Defects in SCNN1B are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.

Specifications

• Antigen: SCNN1B
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: SCNN1B
• Gene Accession No.: P37090, P51168, Q9WU38
• Gene Alias: Amiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; amiloride-sensitive sodium channel subunit beta-like protein; BESC1; Beta ENaC; beta-ENaC; Beta-NaCH; betaxENaC; ENaC beta; ENaCb; enacbeta; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; epithelial sodium channel, nonvoltage-gated 1, beta; nasal epithelial sodium channel beta subunit; nonvoltage-gated sodium channel 1 subunit beta; RNENACB; SCNEB; SCNN 1B; SCNN1B; scnn1b.L; scnn1b-a; scnn1b-b; sodium channel epithelial 1 beta subunit; sodium channel, non voltage gated 1 beta subunit; sodium channel, non voltage gated 1 beta subunit L homeolog; sodium channel, nonvoltage-gated 1 beta; sodium channel, nonvoltage-gated 1, beta; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated, type I, beta; XELAEV_18045378mg
• Gene Symbols: SCNN1B
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human SCNN1B(Accession P51168), corresponding to amino acid residues N587-G637.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20277, 24767, 6338
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG