SELP Rabbit anti-Human, Rat, Polyclonal, liquid, OriGene

Catalog No.	Quantity
50-168-4742	100 μL

Catalog No. 50-168-4742 Supplier OriGene Supplier No. TA890029

Description

Rabbit Polyclonal Antibody

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Specifications

• Antigen: SELP
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene: SELP
• Gene Accession No.: P16109, P98106
• Gene Alias: CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL
• Gene Symbols: SELP
• Host Species: Rabbit
• Immunogen: Recombit protein of human SELP
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 25651, 6403
• Target Species: Human, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG