Invitrogen™ SEMA3C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575455

Catalog No. PIPA575455

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The SEMA3C gene encodes the protein semaphorin 3C, a member of the semaphorin family known for its roles in axonal guidance, cellular signaling, and vascular development. Semaphorin 3C is involved in guiding neurons during development by serving as a repulsive cue, helping establish proper neural network formation through interaction with neuropilin and plexin receptors. It also plays crucial roles in angiogenesis and cardiac development by influencing endothelial cell behavior and migration. In the context of cancer, SEMA3C is implicated in tumor progression, where its dysregulation can promote tumor cell invasion and metastasis by modifying the extracellular matrix and affecting cellular adhesion. Research has demonstrated that SEMA3C can alter the tumor microenvironment, making it a potential target for cancer therapies aimed at inhibiting metastasis and controlling tumor growth. Understanding SEMA3C's function in various biological processes continues, highlighting its significance in developmental biology and disease modulation.

Specifications

• Antigen: SEMA3C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA3C
• Gene Alias: 1110036B02Rik; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; sema E; Sema3c; Semae; semaphorin 3C; semaphorin E; semaphorin-3C; Semaphorin-E; SemE
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10512, 20348, 296787
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q62181, Q99985
• Gene Symbols: SEMA3C
• Immunogen: Synthetic peptide corresponding to amino acids 713-751 of Human SEMA3C.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov