Senataxin Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-9267	100 μL

Catalog No. 50-155-9267 Supplier Bethyl Laboratories, Inc Supplier No. A301105A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3′ transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

Specifications

• Antigen: Senataxin
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: SETX
• Gene Accession No.: Q7Z333
• Gene Alias: ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1
• Gene Symbols: SETX
• Host Species: Rabbit
• Immunogen: Between 2627 and 2677
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23064
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG