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Invitrogen™ SENP6 Polyclonal Antibody
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Catalog No. PIPA5104469
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PIPA5104469 100 μL
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Catalog No. PIPA5104469 Supplier Invitrogen™ Supplier No. PA5104469
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SENP6.

Ubiquitin-like molecules, such as SUMO1, are structurally related to ubiquitin. and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1. to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SENP6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SENP6
Gene Accession No. Q6P7W0, Q9GZR1
Gene Alias 2810017C20Rik; E130319N12Rik; FKSG6; FLJ11355; FLJ11887; KIAA0389; KIAA0797; mKIAA0797; RP1-134M13.1; SENP6; sentrin/SUMO-specific protease SENP6; Sentrin-specific protease 6; Sentrin-specific protease 6-like protein; SSP1; SUMO specific peptidase 6; SUMO/sentrin specific peptidase 6; SUMO/sentrin specific protease 6; SUMO1/sentrin specific peptidase 6; SUMO1/sentrin specific protease 6; Sumo1/sentrin/SMT3 specific peptidase 6; SUMO-1-specific protease 1; Susp1
Gene Symbols SENP6
Host Species Rabbit
Immunogen A synthesized peptide derived from human SENP6(Accession Q9GZR1), corresponding to amino acid residues V758-A808.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 215351, 26054
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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