Invitrogen™ Septin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553814

Catalog No. PIPA553814

Description

Immunogen sequence: WGVVEVENPE HNDFLKLRTM LITHMQDLQE VTQDLHYENF RSERLKRGGR KVENEDMNKD QILLEKEAEL RRMQEMIARM QAQMQMQMQG GDGDGGALGH Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.

Specifications

• Antigen: Septin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEPTIN2
• Gene Alias: 2-Sep; AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD5; Nedd-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Pnutl3; Sept2; septin 2; Septin2; septin-2; Vascular endothelial cell specific protein 11; Vesp11
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117515, 18000, 4735
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P42208, Q15019, Q91Y81
• Gene Symbols: SEPTIN2
• Immunogen: Recombinant protein corresponding to Human Septin 2. Recombinant protein control fragment (Product #RP-90827).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov