Invitrogen™ SERPINB7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555011

Catalog No. PIPA555011

Description

Immunogen sequence: KAVAMMHQER KFNLSVIEDP SMKILELRYN GGINMYVLLP ENDLSEIENK LTFQNLMEWT NPRRMTSKYV EVFFPQFKIE KNYEMKQYLR ALGLKDIFDE SKADLSGIAS GGRLYISRMM HKSYIEVTEE GT Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 72%.

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.

Specifications

• Antigen: SERPINB7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SERPINB7
• Gene Alias: 4631416M05Rik; MEGSIN; mesangium predominant gene, megsin; ovalbumin; PPKN; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin family B member 7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; SERPINB7; Serpin-B7; TP55
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8710
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75635
• Gene Symbols: SERPINB7
• Immunogen: Recombinant protein corresponding to Human SERPINB7. Recombinant protein control fragment (Product #RP-101064).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov