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Invitrogen™ SERPINB7 Polyclonal Antibody
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Catalog No. PIPA555011
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PIPA555011 100 μL
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Catalog No. PIPA555011 Supplier Invitrogen™ Supplier No. PA555011
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KAVAMMHQER KFNLSVIEDP SMKILELRYN GGINMYVLLP ENDLSEIENK LTFQNLMEWT NPRRMTSKYV EVFFPQFKIE KNYEMKQYLR ALGLKDIFDE SKADLSGIAS GGRLYISRMM HKSYIEVTEE GT Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 72%.

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SERPINB7
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SERPINB7
Gene Accession No. O75635
Gene Alias 4631416M05Rik; MEGSIN; mesangium predominant gene, megsin; ovalbumin; PPKN; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin family B member 7; serpin peptidase inhibitor, clade B (ovalbumin), member 7; SERPINB7; Serpin-B7; TP55
Gene Symbols SERPINB7
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SERPINB7. Recombinant protein control fragment (Product #RP-101064).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8710
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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