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SETD7 / SET7 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
$156.65 - $620.58
Specifications
| Antigen | SETD7 / SET7 |
|---|---|
| Concentration | Lot-Specific |
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-3409
|
Active Motif
61452 |
10 μL |
Each for $156.65
|
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50-199-3408
|
Active Motif
61451 |
100 μL |
Each for $620.58
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Description
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.Specifications
| SETD7 / SET7 | |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human | |
| Q8WTS6 | |
| 80854 | |
| This antibody was raised against a peptide within human SETD7 / SET7. | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Setd7 |
| Lot-Specific | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 30% glycerol and 0.035% sodium azide; pH 7.5 | |
| 1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; Lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; SET7/9; Set9; Setd7 | |
| Setd7 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
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