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SETD7 / SET7 Rabbit anti-Human, Unconjugated, Polyclonal, Active Motif™ 
Rabbit Polyclonal Antibody
$135.30 - $534.00
Specifications
| Monoclonal or Polyclonal | Polyclonal |
|---|---|
| Primary or Secondary | Primary |
| Antigen | SETD7 / SET7 |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
50-199-3409
|
Active Motif
61452 |
10 μL |
Each for $135.30
|
|
50-199-3408
|
Active Motif
61451 |
100 μL |
Each for $534.00
|
|
Description
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.Specifications
| Polyclonal | |
| Primary | |
| SETD7 / SET7 | |
| Unconjugated |
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