SETD8 Monoclonal Antibody (OTI2F5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808272

Catalog No. 50-168-2019

Description

Histone methyltransferase that specifically monomethylates ′Lys-20′ of histone H4. H4 ′Lys-20′ monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintece of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.

Specifications

• Antigen: SETD8
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9NQR1
• Gene Symbols: KMT5A
• Immunogen: Full length human recombit protein of human SETD8 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2F5
• Conjugate: Unconjugated
• Gene: KMT5A
• Gene Alias: PR-Set7, SET07, SET8, SETD8
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 387893
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid