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  5. Tocris Bioscience™ SF 1670

Tocris Bioscience™ SF 1670

Catalog No. 502050
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Quantity:
10 mg
50 mg
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Catalog No. 502050

Supplier: Tocris Bioscience™ 5020/50

This item is not returnable. View return policy

Description

PTEN inhibitor

SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Specifications

Chemical Name or Material N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
CAS 345630-40-2
Quantity 50 mg
Target Protein Tyrosine Phosphatase Inhibitors
Molecular Formula C19H17NO3
Formula Weight 307.34
Purity >98%
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