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Invitrogen™ SFRP4 Polyclonal Antibody
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Catalog No. PIPA552679
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PIPA552679 100 μL
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Catalog No. PIPA552679 Supplier Invitrogen™ Supplier No. PA552679
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RHMPWNITRM PNHLHHSTQE NAILAIEQYE ELVDVNCSAV LRFFLCAMYA PICTLEFLHD PIKPCKSVCQ RARDDCEPLM KMYNHSWPES LACDELPVYD RGVCISPEAI VTDLPEDVKW IDITPDMMVQ ERPLDVDCKR Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SFRP4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SFRP4
Gene Accession No. Q6FHJ7
Gene Alias Ddc4; DDC-4 protein; Frizzled protein, human endometrium; frizzled related protein; frizzled-related protein; frizzled-related protein 4; FRP; FRP-4; FRPHE; MGC26498; secreted frizzled related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related sequence protein 4; Sfrp4; sFRP-4
Gene Symbols SFRP4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SFRP4. Recombinant protein control fragment (Product #RP-88742).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6424
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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