Invitrogen™ SFTPB Monoclonal Antibody (SPB02 (1B9))

Catalog No.	Quantity
PIMA1204	100 μg

Catalog No. PIMA1204 Supplier Invitrogen™ Supplier No. MA1204

Description

Mouse Monoclonal Antibody

Detects mature surfactant protein B (8kDa monomer and 16kDa Dimeric forms) and pro surfactant protein B (24kDa) in western blot. Sequence homology: Cow: 86%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 92%; Rabbit: 85%; Rat: 100%; Sheep: 79%.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Specifications

• Antigen: SFTPB
• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: SPB02 (1B9)
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
• Gene: SFTPB
• Gene Accession No.: P07988
• Gene Alias: 18 kDa pulmonary-surfactant protein; 6 kDa protein; AI562151; P SFTB3; pot. surfactant-associated protein precursor; putative; preproprotein; PSP-B; Pulmonary surfactant protein 18; pulmonary surfactant protein B; pulmonary surfactant-associated protein B; pulmonary surfactant-associated protein B precursor; pulmonary surfactant-associated protein B; LOW QUALITY PROTEIN: pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SF-B; SFPB; SFTB3; SFTP3; Sftp-3; Sftpb; SMDP1; SP 18; SP-B; SPBS; surfactant associated protein B; surfactant protein B; surfactant protein-B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
• Gene Symbols: SFTPB
• Host Species: Mouse
• Immunogen: Recombinant Surfactant Protein B.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6439
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a