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SGC 0946, R&D Systems™
SDP

Catalog No. 454150 Shop All Novus Biologicals Products
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Catalog No. Quantity
45-415-0 50 mg
45-411-0 10 mg
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Catalog No. 45-415-0 Supplier R&D Systems Supplier No. 4541/50

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Description

A Tocris product, part of R&D Systems. Highly potent and selective DOT1L inhibitor; cell permeable

Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

Chemical Identifiers

CAS 1561178-17-3
Molecular Formula C28H40BrN7O4
Molecular Weight (g/mol) 618.58
InChI Key IQCKJUKAQJINMK-UHFFFAOYNA-N
Synonym 1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-tert-butyl phenyl urea, d0s9sj, sgc hplc, 1-3-2r,3s,4r,5r-5-4-amino-5-bromopyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxyoxolan-2-yl methyl-propan-2-ylamino propyl-3-4-tert-butylphenyl urea, 1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-2,2-dimethylethyl phenyl urea, 5-bromo-7-5-deoxy-5-3-4-1,1-dimethylethyl phenyl amino carbonyl amino propyl 1-methylethyl amino-beta-d-7h-pyrrolo 2,3-d pyrimidin-4-amine, 5-bromo-7-5-3-4-tert-butylphenyl carbamoyl amino propyl propan-2-yl amino-5-deoxy-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine, aw2
PubChem CID 56962337

Specifications

Quantity 50 mg
Formula Weight 618.57
Percent Purity >99%
Product Line Tocris
Chemical Name or Material SGC 0946

Safety and Handling

Recommended Storage Store at -20°C
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