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SGC 0946, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1561178-17-3
C28H40BrN7O4
618.58
IQCKJUKAQJINMK-UHFFFAOYNA-N
1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-tert-butyl phenyl urea,d0s9sj,sgc hplc,1-3-2r,3s,4r,5r-5-4-amino-5-bromopyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxyoxolan-2-yl methyl-propan-2-ylamino propyl-3-4-tert-butylphenyl urea,1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-2,2-dimethylethyl phenyl urea,5-bromo-7-5-deoxy-5-3-4-1,1-dimethylethyl phenyl amino carbonyl amino propyl 1-methylethyl amino-beta-d-7h-pyrrolo 2,3-d pyrimidin-4-amine,5-bromo-7-5-3-4-tert-butylphenyl carbamoyl amino propyl propan-2-yl amino-5-deoxy-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine,aw2
56962337
This item is not returnable. View return policy
1561178-17-3
C28H40BrN7O4
618.58
IQCKJUKAQJINMK-UHFFFAOYNA-N
1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-tert-butyl phenyl urea,d0s9sj,sgc hplc,1-3-2r,3s,4r,5r-5-4-amino-5-bromopyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxyoxolan-2-yl methyl-propan-2-ylamino propyl-3-4-tert-butylphenyl urea,1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-2,2-dimethylethyl phenyl urea,5-bromo-7-5-deoxy-5-3-4-1,1-dimethylethyl phenyl amino carbonyl amino propyl 1-methylethyl amino-beta-d-7h-pyrrolo 2,3-d pyrimidin-4-amine,5-bromo-7-5-3-4-tert-butylphenyl carbamoyl amino propyl propan-2-yl amino-5-deoxy-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine,aw2
56962337

Highly potent and selective DOT1L inhibitor; cell permeable

Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

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Quantity 10mg
Formula Weight 618.57
Percent Purity >99%
Chemical Name or Material SGC 0946

Recommended Storage : Store at -20°C