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Invitrogen™ SH2D1A Polyclonal Antibody
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Catalog No. PIPA5102364
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PIPA5102364 100 μL
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Catalog No. PIPA5102364 Supplier Invitrogen™ Supplier No. PA5102364
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SH2D1A.

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SH2D1A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Sh2d1a
Gene Accession No. B2RZ59, O60880, O88890
Gene Alias DSHP; Duncan disease homolog; Duncan disease SH2-protein; Duncan's disease; EBVS; FLJ18687; FLJ92177; Gm686; HGNC:10820; IMD5; LYP; MTCP1; RGD1562408; RP5-1052M9.3; SAP; SAP/SH2D1A; SH2 domain containing 1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; Xlp; XLPD; XLPD1
Gene Symbols Sh2d1a
Host Species Rabbit
Immunogen A synthesized peptide derived from human SH2D1A(Accession O60880), corresponding to amino acid residues T53-E103.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20400, 4068, 501502
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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