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SHARPIN Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501989178
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50-198-9178 100 μL
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Catalog No. 50-198-9178 Supplier Bioss Supplier No. BS9581R
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Description

Rabbit Polyclonal Antibody

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Specifications

Antigen SHARPIN
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SHARPIN
Gene Accession No. Q9H0F6
Gene Alias 0610041B22Rik; AW121341; BOS_13657; Conneck1; Cpdm; hSIPL1; mSIPL1; protein kinase C-interacting protein RBCC like 1; PSEC0216; RBCKL1; SHANK associated RH domain interactor; SHANK-associated RH domain interacting protein; SHANK-associated RH domain interactor; Shank-associated RH domain-interacting protein; shank-interacting protein; Shank-interacting protein-like 1; Sharpin; SIPL1
Gene Symbols SHARPIN
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SHARPIN.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81858
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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