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Invitrogen™ Shiga like-toxin 1 Monoclonal Antibody (13C4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA140277

Catalog No. 01-676-396


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Description

Description

MA1-40277 detects Shigatoxin 1 from E. coli samples. MA1-40277 has been successfully used in ELISA, functional assays and Western blot applications. The MA1-40277 immunogen is 1B subunit of Shigatoxin 1.

Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Shiga like-toxin 1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
Mouse
Protein G
RUO
Bacteria
Antibody
IgG1
ELISA, Functional Assay, Western Blot
13C4
Unconjugated
SLT1; SLT-1; SLTI; SLT-I; Verocytotoxin; Verotoxin
1B subunit of Shigatoxin 1.
100 μg
Primary
4°C
Liquid
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