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Invitrogen™ Shiga like-toxin 1 Monoclonal Antibody (13C4)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA140277
Description
MA1-40277 detects Shigatoxin 1 from E. coli samples. MA1-40277 has been successfully used in ELISA, functional assays and Western blot applications. The MA1-40277 immunogen is 1B subunit of Shigatoxin 1.
Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
Specifications
Shiga like-toxin 1 | |
Monoclonal | |
0.1 mg/mL | |
PBS with 0.1% BSA and no preservative | |
Mouse | |
Protein G | |
RUO | |
Bacteria | |
Antibody | |
IgG1 |
ELISA, Functional Assay, Western Blot | |
13C4 | |
Unconjugated | |
SLT1; SLT-1; SLTI; SLT-I; Verocytotoxin; Verotoxin | |
1B subunit of Shigatoxin 1. | |
100 μg | |
Primary | |
4°C | |
Liquid |
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