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Invitrogen™ Shiga toxin 2A Monoclonal Antibody (11E10)
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Catalog No. PIMA533371
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100 μg
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PIMA533371 100 μg
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Catalog No. PIMA533371 Supplier Invitrogen™ Supplier No. MA533371
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Description

Mouse Monoclonal Antibody

Product is supplied at 1 mL (100 μL/mL). Application Notes: Functional assay - For inhibition of biological activity in vitro dilutions have to be made according to the amounts of toxin to be inactivated. ELISA - antibody can be used as detector.

Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Shiga toxin 2A
Applications ELISA, Functional Assay, Western Blot
Classification Monoclonal
Clone 11E10
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene Alias Shiga toxin; Shigatoxin Type 2; Shigatoxin Type II; STX2; STX-2a; STX-IIa
Host Species Mouse
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Bacteria
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
Target Molecule Chemical
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