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Invitrogen™ SHISA4 Polyclonal Antibody, Invitrogen™

Catalog No. p-7240979
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20 μL
100 μL
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Catalog No. Quantity
PIPA5121852 20 μL
PIPA5121851 100 μL
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Catalog No. PIPA5121852 Supplier Invitrogen™ Supplier No. PA5121852
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Description

Rabbit Polyclonal Antibody

SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHISA4
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene SHISA4
Gene Accession No. Q8CA71, Q96DD7
Gene Alias 9330132O05Rik; C1orf40; mShisa4; Protein shisa-4; shisa family member 4; shisa homolog 4; SHISA4; Tmem58; transmembrane protein 58; UNQ583/PRO1153
Gene Symbols SHISA4
Host Species Rabbit
Immunogen Gly28-Ala197 (Accession Q96DD7), with N-terminal His Tag.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 149345, 360848, 77552
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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