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SHISA4 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501733765 Shop All Proteintech Group Inc Products
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50-173-3765 150 μL
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Catalog No. 50-173-3765 Supplier Proteintech Group Inc Supplier No. 221971AP150UL
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Description

Rabbit Polyclonal Antibody

SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Specifications

Antigen SHISA4
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.39 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SHISA4
Gene Accession No. Q8CA71, Q96DD7
Gene Alias C1orf40, hShisa4, Protein shisa 4, SHISA4, TMEM58, Transmembrane protein 58
Gene Symbols SHISA4
Host Species Rabbit
Immunogen SHISA4 Fusion Protein Ag17357
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 149345, 77552
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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