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  6. Invitrogen™ SIGLEC H Monoclonal Antibody (eBio440c), Super Bright™ 436, eBioscience™, Invitrogen™ 

Invitrogen™ SIGLEC H Monoclonal Antibody (eBio440c), Super Bright™ 436, eBioscience™, Invitrogen™
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Catalog No. p-7159120
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100 μg
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Catalog No. Quantity
62-033-382 100 μg
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Catalog No. 62-033-382 Supplier Invitrogen™ Supplier No. 62033382
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Description

Rat Monoclonal Antibody

The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+

Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC H
Applications Flow Cytometry
Classification Monoclonal
Clone eBio440c
Concentration 0.2 mg/mL
Conjugate Super Bright 436
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Siglech
Gene Accession No. 0
Gene Alias 6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein
Gene Symbols Siglech
Host Species Rat
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 233274
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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