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Invitrogen™ SIGLEC12 Polyclonal Antibody
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Catalog No. PIPA531457
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100 μL
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PIPA531457 100 μL
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Catalog No. PIPA531457 Supplier Invitrogen™ Supplier No. PA531457
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: MCF-7. Predicted reactivity: Chimpanzee (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC12
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.99 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SIGLEC12
Gene Accession No. Q96PQ1
Gene Alias Cd170; MIS; mSiglec-E; Myeloid inhibitory siglec; S2V; sialic acid binding Ig like lectin 12 (gene/pseudogene); sialic acid binding Ig-like lectin 12; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin E; sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin 5; sialic acid-binding Ig-like lectin E; Sialic acid-binding Ig-like lectin-like 1; sialic acid-binding immunoglobulin-like lectin E; Siglec; SIGLEC12; siglec-12; Siglec5; Siglec-5; Siglec9; Siglece; siglec-E; Siglecl1; Siglec-L1; SIGLEC-like 1; Siglec-XII; SLG; UNQ9215/PRO34042
Gene Symbols SIGLEC12
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human SIGLEC12. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 89858
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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