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Invitrogen™ SIGLEC5/SIGLEC14 Monoclonal Antibody (1A5), FITC
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Catalog No. PIMA528138
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100 μg
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Catalog No. Quantity
PIMA528138 100 μg
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Catalog No. PIMA528138 Supplier Invitrogen™ Supplier No. MA528138
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Description

Mouse Monoclonal Antibody

This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.

SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC5/SIGLEC14
Applications Flow Cytometry
Classification Monoclonal
Clone 1A5
Concentration 100 μg/mL
Conjugate FITC
Formulation PBS with 1% BSA and 0.09% sodium azide
Gene SIGLEC5
Gene Accession No. O15389, Q08ET2
Gene Alias CD170; CD33 antigen-like 2; CD33L2; LLNLR-470E3.1; OB-binding protein 2; OBBP2; OB-BP2; obesity-binding protein 2; sialic acid binding Ig like lectin 14; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; SIGLEC14; siglec-14; SIGLEC5; Siglec-5; UNQ294/PRO333
Gene Symbols SIGLEC14, SIGLEC5
Host Species Mouse
Immunogen Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100049587, 8778
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG1
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