SIGLEC6 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8757	Proteintech Group Inc 134541AP150UL	150 μL

Description

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predomitly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Specifications

• Antigen: SIGLEC6
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O43699
• Gene ID (Entrez): 946
• Immunogen: SIGLEC6 Fusion Protein Ag4281
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SIGLEC6

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CD327, CD33 antigen like 1, CD33L, CD33L1, CDw327, OB BP1, OBBP1, Obesity binding protein 1, SIGLEC 6, SIGLEC6
• Gene Symbols: SIGLEC6
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody