Invitrogen™ Sigma-1 Receptor Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 423300

Catalog No. 42-330-0

Description

This antibody is specific for the sigma-1 receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1) protein. On western blots, it identifies the target band at ~25 kDa. Reactivity has been confirmed with rat brain, rat liver, and mouse brain homogenates. Based on amino acid sequence identity, reactivity with human, bovine, dog, and ermine is expected.

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

Specifications

• Antigen: Sigma-1 Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGMAR1
• Gene Alias: AAG8; Aging-associated gene 8 protein; AL024364; ALS16; DSMA2; hSigmaR1; mSigmaR1; opioid receptor, sigma 1; Oprs1; RP23 167I12.6; SIG 1R; SIG-1R; sigma 1 receptor variant SR-1D; sigma 1-type opioid receptor; Sigma non-opioid intracellular receptor 1; sigma1 receptor; Sigma-1 Receptor; sigma1R; sigma1-receptor; Sigmar1; SR BP; SR31747 binding protein 1; SR31747-binding protein; SRBP; SR-BP; SR-BP1; zgc:56378
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18391, 29336
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O55242, Q9R0C9
• Gene Symbols: SIGMAR1
• Immunogen: Synthetic peptide derived from the C-terminal region of the rat sigma-1 receptor, which differs from mouse and human by one conservative amino acid change and is predicted to be identical to dog, bovine, and ermine.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG