SIP1 Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3154	Active Motif 61114	10 μL
50-199-3153	Active Motif 61113	100 μL

Description

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Specifications

• Antigen: SIP1
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O60315
• Gene ID (Entrez): 9839
• Immunogen: This SIP1 antibody was raised against a peptide from the N-terminus of human SIP1.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: Zeb2

• Concentration: Lot-Specific
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Alias: 9130203F04Rik; BOS_1771; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; Sip1; SIP-1; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zeb2; Zfhx1b; ZFX1B; Zfxh1b; zinc finger E-box binding homeobox 2; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b
• Gene Symbols: Zeb2
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody