SIRT1 Monoclonal Antibody (OTI12H3), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3060	100 μL

Catalog No. 50-168-3060 Supplier OriGene Supplier No. TA809859

Description

Mouse Monoclonal Antibody

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metobolism, apoptosis, and authopahy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5′-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Specifications

• Antigen: SIRT1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI12H3
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: SIRT1
• Gene Accession No.: Q96EB6
• Gene Alias: SIR2, SIR2L1, SIR2alpha
• Gene Symbols: SIRT1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 552-676 of human SIRT1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23411
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b