Invitrogen™ Sirtratumab Recombinant Human Monoclonal Antibody

Catalog No.	Quantity
PIMA542160	100 μg

Catalog No. PIMA542160 Supplier Invitrogen™ Supplier No. MA542160

Description

Human Recombinant Monoclonal Antibody

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Sirtratumab is a biosimilar that targets SLITRK6. SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. At least two isoforms of Slitrk6 are known to exisit.

Specifications

• Antigen: Sirtratumab
• Applications: ELISA, SDS-Page
• Classification: Recombinant Monoclonal
• Concentration: 1.37 mg/mL
• Conjugate: Unconjugated
• Formulation: 30mM histidine with 10% sucrose, 0.06% Tween 80 and no preservative; pH 5.8
• Gene Alias: AGS15C; Ha15-10ac12; Ha15-10ac12.1
• Host Species: Human
• Immunogen: Human SLITRK6.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2 κ
• Target Molecule: Chemical