SIX5 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-3968	150 μL

Catalog No. 50-173-3968 Supplier Proteintech Group Inc Supplier No. 229381AP150UL

Description

Rabbit Polyclonal Antibody

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintece of retinal formation. Six5 is able to bind the 5′-TCA[AG][AG]TTNC-3′ DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.

Specifications

• Antigen: SIX5
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.47 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: SIX5
• Gene Accession No.: Q8N196
• Gene Alias: BOR2, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5, SIX homeobox 5, SIX5
• Gene Symbols: SIX5
• Host Species: Rabbit
• Immunogen: SIX5 Fusion Protein Ag18993
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 147912
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG