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Tocris SJF 8240

c-MET PROTAC™; also degrades exon-14-deleted c-MET

Manufacturer:  Tocris 7266/5

Catalog No. 72-665


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Description

Description

SJF 8240 is a c-MET PROTAC™Degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifications

Specifications

C58H65F2N7O11S
N-(3-Fluoro-4-((7-(3-(3-(3-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic
2230821-68-6
0.98
Active Degraders
5 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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