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Invitrogen™ SKI Polyclonal Antibody
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Catalog No. PIPA5119873
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100 μL
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PIPA5119873 100 μL
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Catalog No. PIPA5119873 Supplier Invitrogen™ Supplier No. PA5119873
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Description

Rabbit Polyclonal Antibody

Positive Control: HUVEC cell lysates, rat skeletal muscle tissue lysate, mouse kidney tissue lysate, human kidney tissue. Subcellular Location: Nucleus.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SKI
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene SKI
Gene Accession No. P12755, Q60698
Gene Alias 2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088; C-ski; Proto-oncogene c-Ski; RGD1565591; SGS; SKI; Ski oncogene; ski oncoprotein; SKI proto-oncogene; ski sarcoma viral oncogene homolog; ski sarcoma viral oncogene homolog (avian); SKV; Sloan-Kettering viral oncogene homolog; v-ski avian sarcoma viral oncogene homolog
Gene Symbols SKI
Host Species Rabbit
Immunogen Recombinant protein within human SKI aa 250-450.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20481, 313757, 6497
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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