Invitrogen™ SLC22A18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536212

Catalog No. PIPA536212

Description

This antibody detects endogenous protein at a molecular weight of 43 kDa. Purity is >95% by SDS-PAGE.

ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations based on a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.

Specifications

• Antigen: SLC22A18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC22A18
• Gene Alias: AW260131; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; BWR1A; BWSCR1A; Efflux transporter-like protein; HET; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Impt1; ITM; Multi-membrane-spanning polyspecific transporter; ORCTL2; ORCTL-2; Organic cation transporter-like protein 2; organic cationic transporter-like 2; p45 Beckwith-Wiedemann region 1A; p45-Beckwith-Wiedemann region 1 A; p45-BWR1A; SLC22A18; SLC22A1L; solute carrier family 22 (organic cation transporter), member 18; Solute carrier family 22 member 18; Solute carrier family 22 member 1-like; solute carrier family 22, member 18; TSSC5; tumor suppressing subtransferable candidate 5; tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18400, 309131, 5002
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: Q6AY78, Q78KK3, Q96BI1
• Gene Symbols: SLC22A18
• Immunogen: Synthetic peptide corresponding to amino acids 360-412 of human ORCTL2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG